GPCRdb: the G protein‐coupled receptor database – an introduction

GPCRdb: the G protein‐coupled receptor database – an introduction

GPCRs make up the largest family of human membrane proteins and of drug targets. Recent advances in GPCR pharmacology and crystallography have shed new light on signal transduction, allosteric modulation and biased signalling, translating into new mechanisms and principles for drug design. The GPCR database, GPCRdb, has served the community for over 20 years and has recently been extended to in...

GPCRDB: an information system for G protein-coupled receptors

The GPCRDB is a G protein-coupled receptor (GPCR) database system aimed at the collection and dissemination of GPCR related data. It holds sequences, mutant data and ligand binding constants as primary (experimental) data. Computationally derived data such as multiple sequence alignments, three dimensional models, phylogenetic trees and two dimensional visualization tools are added to enhance t...

The Design of Query Interfaces to the GPCRDB Biological Database

In this paper, we describe the query interfaces of a practical biological database system-GPCRDB. Distinguishing features of the system include: an embedded smart query engine (for query relaxation), smooth integration of navigation with the more conventional SQL-based query mechanisms , and the top-down style of incremental query result presentation combined with flexible navigation capabiliti...

A direct and functional interaction between the trimeric G protein Go and Rab5 in G proteincoupled receptor signaling

ترجمه و تحقیق کتاب an introduction to the history of mysticism

پایان نامه ی ارائه شده ترجمه ی کتاب «an introduction to the history of mysticism» نوشته ی مارگارت اسمیت که وی پژوهشگر، خاورشناس و محقق برجسته ی تصوف و عرفان می باشد. موضوع اساسی و مهم این کتاب عرفان در ادیان مختلف است. نویسنده در ابتدا این کلمه را ریشه یابی کرده و سپس تعریفی از آن ارائه داده و آن را در ادیان مختلف مورد بحث قرار داده است و در هر فصل کتاب به معرفی عرفای آن دین یا عصر خاصی پرداخته...